Як цитувати

Ruszała, M., Dłuski, D., Zamojska, A., Wańkowicz, A., & Gogacz, M. (2021). ENDOMETRIOSIS AND OXIDATIVE-ANTIOXIDATIVE IMBALANCE STATUS. THE ROLE OF FLAVONOIDS, CURCUMIN AND N-ACETYLCYSTEINE. InterConf, (49), 477-483. https://doi.org/10.51582/interconf.7-8.04.2021.050


Endometriosis is a silent, unseen and painful female illness which is characterized by the presence of glands and stroma outside the uterine cavity. Approximately one in ten women in a reproductive age around the world suffer from endometriosis of whom nearly half is treated due to infertility. The pathogenesis and mechanisms that determines the occurence of the disease are still unknown. Immunological factors have been observed in the initiation and development of endometriosis. An imbalance between reactive oxygen species (molecules having an unpaired electron) and antioxidants leads to the upregulation of metalloproteinases, prostaglandins, cytokines and chemokines.



Vallée A, Lecarpentier Y. Curcumin and Endometriosis. Int J Mol Sci. 2020;21(7):2440

Estes SJ, Huisingh CE, Chiuve SE, Petruski-Ivleva N, Missmer SA. Depression, Anxiety, and Self-directed Violence in Women with Endometriosis: A Retrospective Matched Cohort Study. Am J Epidemiol. 2020 Nov 13: kwaa249

Zheng W, Wu J, Gu J, Weng H, Wang J, Wang T, Liang X, Cao L. Modular Characteristics and Mechanism of Action of Herbs for Endometriosis Treatment in Chinese Medicine: A Data Mining and Network Pharmacology-Based Identification. Front Pharmacol. 2020 Mar 6; 11:147

onnez J, Binda MM, Donnez O, Dolmans MM. Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis. Fertil Steril. 2016 Oct;106(5):1011-1017

Tsamantioti ES, Mahdy H. Endometriosis. 2021 Feb 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 33620854

Anastasiu CV, Moga MA, Elena Neculau A, Bălan A, Scârneciu I, Dragomir RM, Dull AM, Chicea LM. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. Int J Mol Sci. 2020 Mar 4;21(5):1750

Ahn SH, Monsanto SP, Miller C, Singh SS, Thomas R, Tayade C. Pathophysiology and Immune Dysfunction in Endometriosis. Biomed Res Int. 2015; 2015:795976

Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D, Bitto A. Oxidative Stress: Harms and Benefits for Human Health. Oxid Med Cell Longev. 2017; 2017:8416763

Nisolle M, Donnez J. Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. Fertil Steril. 1997; 68: 585-596

Berbic M, Schulke L, Markham R et al. Macrophage expression in endometrium of women with and without endometriosis. Hum Reprod 2009; 24:325–32

Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012 Jul 6;18(7):1028-40

Huang E, Peng N, Xiao F, Hu D, Wang X, Lu L. The Roles of Immune Cells in the Pathogenesis of Fibrosis. Int J Mol Sci. 2020 Jul 22;21(15):5203

Balan A, Moga MA, Dima L, Dinu CG, Martinescu CC, Panait DE, Irimie CA, Anastasiu CV. An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants. Plants (Basel). 2021 Mar 20;10(3):587

Khazaei MR, Rashidi Z, Chobsaz F, Niromand E, Khazaei M. Inhibitory effect of resveratrol on the growth and angiogenesis of human endometrial tissue in an In Vitro three-dimensional model of endometriosis. Reprod Biol. 2020 Dec;20(4):484-490

Arablou T, Aryaeian N, Khodaverdi S, Kolahdouz-Mohammadi R, Moradi Z, Rashidi N, Delbandi AA. The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis. Sci Rep. 2021 Mar 15;11(1):6054

Nodler, James & Harris, Holly & Chavarro, Jorge & Frazier, A. & Missmer, Stacey. (2019). Dairy consumption during adolescence and endometriosis risk. American Journal of Obstetrics and Gynecology. 222. 10.1016/j.ajog.2019.09.010.

Vallée A, Lecarpentier Y. Curcumin and Endometriosis. Int J Mol Sci. 2020 Mar 31;21(7):2440

Arablou T., Kolahdouz-Mohammadi R. Curcumin and endometriosis: Review on potential roles and molecular mechanisms. Biomed. Pharmacother. 2018; 97:91–97

Kim K.-H., Lee E.N., Park J.K., Lee J.-R., Kim J.-H., Choi H.-J., Kim B.-S., Lee H.-W., Lee K.-S., Yoon S. Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells. Phytother. Res. 2012; 26:1037–1047

Porpora M, Brunelli R, Costa G. A promise in the treatment of endometriosis: an observational cohort study on ovarian endometrioma reduction by N-acetylcysteine. Evid Based Complement Alternat Med. 2013; 2013: 240702

Maybin JA, Critchley HOD, Jabbour HN. Inflammatory pathways in endometrial disorders. Molecular and Cellular Endocrinology. 2011;335(1):42–51

Lu H, Hu H, Yang Y, Li S. The inhibition of reactive oxygen species (ROS) by antioxidants inhibits the release of an autophagy marker in ectopic endometrial cells. Taiwan J Obstet Gynecol. 2020 Mar;59(2):256-261

Lete I, Mendoza N, de la Viuda E, Carmona F. Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study. Eur J Obstet Gynecol Reprod Biol. 2018 Sep; 228:221-224

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